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Alessandro Maria Morelli investigated on the enzyme Glucose-6-P-dehydrogenase and on it’s molecular mechanism of senescence, on the phototransducion molecular events in photoreceptor cells of vertebrate retina and, more general, on bioenergetics topic specifically linked to neurofisiology. He has discovered the protein FX, a NADP dependent enzyme, catalizing synthesis of GDP-L-fucose. He has been working on the effects of electromagnetic fields of extremely low frequency on the activity of enzymes involved in phototransduction in retinal cells of vertebrates. Moreover, he has put in evidence the reversible effects of electromagnetic fields on lipid-linked enzymes such as acetylcholinesterase of retinal synaptosomes. Recently, with Isabella Panfoli, Silvia Ravera, Daniela Calzia, has discovered the brain myelin energetic function and the ATP extramitochondrial synthesis operating in it, involving new paradigms for Neurobiology, with application in the study of Multiple Sclerosis and other neurodegenerative deseases.